标准化分析 > RNA测序 > circRNA测序 > circRNA
circRNA测序
环状RNA(circRNA)是一类特殊的非编码RNA分子,与传统的线性RNA(linear RNA)不同,circRNA分子合呈封闭环状结构,且不受RNA外切酶影响,表达更稳定,不易降解。环状RNA测序能够进行环状RNA的鉴定以及环状RNA与miRNA海绵效应分析, 可实现ceRNA(源竞争RNA)机制等研究。
技术优势
方法灵活:可以使用去核糖体建库测序数据分析环状RNA;
结果可靠:采用多种软件对环状RNA进行鉴定和预测;
实验严谨:R酶建库方法稳定,去除线性RNA效率高;
分析经验丰富:完成了数千份数据的分析。
产品应用
![](data:image/png;base64,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)
信息分析内容
一、标准信息分析
1. 基本数据统计
1.1去除接头序列、低质量序列得到clean data
1.2与核糖体数据库比对,去除核糖体RNA数据
2. 环状RNA预测鉴定
3. 环状RNA所在线性基因注释
4. 环状RNA在基因组上的定位
5. 环状RNA表达定量分析
6. 样品(组)间表达差异分析
二、高级信息分析
1. 差异环状RNA来源的基因GO功能及富集分析
2. 差异环状RNA来源的基因Pathway功能及富集分析
3. 环状RNA与miRNA互作分析(适用于人/小鼠物种)
环状RNA(circRNA)是一类特殊的非编码RNA分子,与传统的线性RNA(linear RNA)不同,circRNA分子合呈封闭环状结构,且不受RNA外切酶影响,表达更稳定,不易降解。环状RNA测序能够进行环状RNA的鉴定以及环状RNA与miRNA海绵效应分析, 可实现ceRNA(源竞争RNA)机制等研究。
技术优势
方法灵活:可以使用去核糖体建库测序数据分析环状RNA;
结果可靠:采用多种软件对环状RNA进行鉴定和预测;
实验严谨:R酶建库方法稳定,去除线性RNA效率高;
分析经验丰富:完成了数千份数据的分析。
产品应用
信息分析内容
一、标准信息分析
1. 基本数据统计
1.1去除接头序列、低质量序列得到clean data
1.2与核糖体数据库比对,去除核糖体RNA数据
2. 环状RNA预测鉴定
3. 环状RNA所在线性基因注释
4. 环状RNA在基因组上的定位
5. 环状RNA表达定量分析
6. 样品(组)间表达差异分析
二、高级信息分析
1. 差异环状RNA来源的基因GO功能及富集分析
2. 差异环状RNA来源的基因Pathway功能及富集分析
3. 环状RNA与miRNA互作分析(适用于人/小鼠物种)